Opium for Women by Yves Saint Laurent Eau de Parfum Spray 50ml

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Opioids can reduce the intensity and unpleasant feeling of pain. The unspecific effect of opium to the different opioid receptors produce the generation of various effects such as sedation, euphoria, dysphoria, respiratory depression, constipation, pruritus, nausea, and vomiting. It is reported that the secondary effects tend to be diminished as long-term use tolerance is developed. Some reports have also shown an opioid-driven impairment of the hypothalamic function that can result in a loss of libido, impotence, and infertility. Patients have reported a sensation of stress relief even in presence of pain as well as the presence of sedation, hypoventilation, cough inhibition, prolonged apnea, myosis and respiratory obstruction. 9 German scientist Friedrich Sertürner first isolated morphine from opium in 1803. Morphine, a very powerful painkiller, is the active narcotic ingredient in opium. The first known cultivation of opium poppies was in Mesopotamia, approximately 3400 BCE, by Sumerians, who called the plant hul gil, the "joy plant". [11] [12] Tablets found at Nippur, a Sumerian spiritual center south of Baghdad, described the collection of poppy juice in the morning and its use in production of opium. [1] Cultivation continued in the Middle East by the Assyrians, who also collected poppy juice in the morning after scoring the pods with an iron scoop; they called the juice aratpa-pal, possibly the root of Papaver. [13] Opium production continued under the Babylonians and Egyptians. The opium trade faced intense enmity from the later British Prime Minister William Ewart Gladstone. [33] As a member of Parliament, Gladstone called it "most infamous and atrocious" referring to the opium trade between China and British India in particular. [34] Gladstone was fiercely against both of the Opium Wars and ardently opposed to the British trade in opium to China. [35] He lambasted it as "Palmerston's Opium War" and said that he felt "in dread of the judgments of God upon England for our national iniquity towards China" in May 1840. [36] Gladstone criticized it as "a war more unjust in its origin, a war more calculated in its progress to cover this country with permanent disgrace,". [37] His hostility to opium stemmed from the effects of opium brought upon his sister Helen. [38] Due to the First Opium war brought on by Palmerston, there was initial reluctance to join the government of Peel on part of Gladstone before 1841. [39] Domestication and suppression in the last decades of the Qing dynasty [ edit ] Chinese opium smokers c. 1858 Fay, Peter Ward (9 November 2000). The Opium War, 1840-1842: Barbarians in the Celestial Empire in the Early Part of the Nineteenth Century and the War by which They Forced Her Gates Ajar. Univ of North Carolina Press. ISBN 978-0-8078-6136-3.

Brook, Timothy; Wakabayashi, Bob Tadashi (2000). Opium Regimes: China, Britain, and Japan, 1839–1952. University of California Press. ISBN 9780520222366. Heroin is classified as a Schedule I drug under the Controlled Substances Act of 1970 and as such has no acceptable medical use in the United States. Greenberg, Michael (1969). British Trade and the Opening of China, 1800–42. Cambridge Studies in Economic History. Cambridge: Cambridge University Press. Smoking of opium declined in the 20th century, partly because it had been supplanted by more-potent derivatives and partly because of determined efforts in China and other developing countries to eradicate it. In the late 1990s, drug-control programs headed by the United Nations and by individual governments contributed to a reduction in opium poppy cultivation in the Golden Triangle. However, the region subsequently became a major producer of other illicit substances, including methamphetamines.Opium dens were places where opium could be bought and sold, and were also found worldwide, especially in Southeast Asia, China and Europe. Withdrawal symptoms usually start six to 24 hours after the last dose and can last around seven to ten days. These symptoms are described as flu-like, and can include: Chen P, Braithwaite RA, George C, Hylands PJ, Parkin MC, Smith NW, Kicman AT: The poppy seed defense: a novel solution. Drug Test Anal. 2014 Mar;6(3):194-201. doi: 10.1002/dta.1590. Epub 2013 Dec 12. [ Article] of opioid consumption is not heroin, but legally produced’ … Photograph: Towfiqu Photography/Getty Images The protein binding of the alkaloids that form opium, such as morphine and codeine, can range from 20-60% depending on the specific alkaloid. The highest binding proteins for opium alkaloids are albumin and beta-globulin II. 5 Metabolism

United States Congress Senate Committee on the Judiciary. Communist china and illicit narcotic traffic. 1955年: United States Government Printing Office. OCLC 6466332. {{ cite book}}: CS1 maint: location ( link) Alcohol, caffeine, nicotine and opium effectively short-circuit our brain’s reward system. They induce the release of dopamine in the mesolimbic pathway – or inhibit the removal of dopamine or make the receptors on the surface of neurones more sensitive – and in some cases they can produce pleasure, even euphoria, far more intense than anything encountered in the natural world. And unlike natural dopamine triggers, such as eating, they never result in satiation. The chief superintendent of trade for the British in China, Capt Charles Elliot, attempted to defuse the standoff. He was able to persuade the traders in Guangzhou to turn over a staggering 1,700 tonnes of opium from the port storehouses by promising that the British government would reimburse them for their losses. Lin disposed of the seized opium, which was hugely valuable, by having it mixed with water and lime in huge pits and then dumping the sludge into the Pearl River. The drugs bust was so large that it took three weeks to destroy it all. Commissioner Lin thought he was doing his honourable duty to stamp out the illegal smuggling of opium that was eating away at his countrymen; but the events that day would lead to a clash of empires and a humiliating defeat for China. Opium produces its effects by activating specific G protein-coupled receptors in the brain, spinal cord, and peripheral nervous system. There are three major classes of opioid receptors being δ-opioid, κ-opioid and μ-opioid. Opium will generate an agonist activity which will later open the potassium channels and prevent the opening of voltage-gated calcium channels. This activity causes a reduction in neuronal excitability and inhibits the release of pain neurotransmitters. 9 Four substances in particular came to have widespread usage around the world: alcohol, caffeine, nicotine and opium. Each has been used widely as a recreational drug – that is, one taken socially or for pleasure rather than for medicinal purposes. While each of these have different effects on our central nervous system, they also all act to trigger a specific part of the brain.

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For the illegal drug trade, the morphine is extracted from the opium latex, reducing the bulk weight by 88%. It is then converted to heroin which is almost twice as potent, [6] and increases the value by a similar factor. The reduced weight and bulk make it easier to smuggle. Liu HC, Ho HO, Liu RH, Yeh GC, Lin DL: Urinary excretion of morphine and codeine following the administration of single and multiple doses of opium preparations prescribed in Taiwan as "brown mixture". J Anal Toxicol. 2006 May;30(4):225-31. [ Article] Taken orally, opium was used medically to treat pain. The morphine is able to bind to nerve cell receptors (which are normally targets for the body’s own hormones, such as endorphins) in parts of the brain involved in the sensation of pain, such as the thalamus, brainstem and spinal cord. But opiates also bind to receptors in the mesolimbic reward pathway, and so beyond its medicinal properties, opium was therefore craved as a recreational drug. Felbab-Brown, Vanda (2009). "The Political Economy of Illegal Domains in India and China". The International Lawyer. 43 (4): 1411–1428. ISSN 0020-7810. JSTOR 40708079. But although opium poppy provided a source of funding for Mao's opponents, and although ideologically it was an anathema to him, Mao too did not attempt to interfere with the poppy economy during his insurgency years. Large segments of the population were dependent upon the poppy economy, and Mao was in turn in need of the rural population's support, or at least its tolerance of his anti-Chiang Kai-shek insurgency. Over time, not only did Mao tolerate poppy cultivation, he actually came to tax it as well.